Chlorhexidine salts have a very wide range of antimicrobial activity, being effective either against gram-positive or gram-negative organisms. They also have fungicidal and sporicidal effect (the latter one at higher temperatures).
Chlorhexidine has a strong basic character with cationic properties. It is available in both freebase and stable salts forms. Chlorhexidine is slightly soluble in water and most organic solvents and because of this poor solubility. It is mainly used in salt form.
Due to the cationic character of Chlorhexidine salts, they are chemically compatible with other cationic and non-ionic substances, but are chemically incompatible with anionic compounds (sulphates, phosphates, carbonates, …).
Medichem manufactures 4 Chlorhexidine compounds:
- Chlorhexidine Base
- Chlorhexidine Digluconate 20% solution
- Chlorhexidine Diacetate
- Chlorhexidine Dihydrochloride
The main features of Chlorhexidine salts manufactured by Medichem are the very low content of impurities specially p-Chloroaniline and the consistent quality. This can only be achieved by a very careful and advanced process, carried out according to Good Manufacturing Practices and to a Quality Management System, certified according to ISO 9001 guidelines in our FDA inspected factory. Since July 2001 Medichem is also certified according to ISO 14001 Environmental Management System.
It is Medichem’s purpose, to excel and provide the highest quality, going beyond the Pharmacopoeias. Medichem has contributed to the development of the new EP and USP monographs for all Chlorhexidine salts. These new monographs represent an enhanced and up to date standard with limits for individual impurities according to ICH guidances.